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Ropinirole , sold under the brand name Requip among others, is a medication used to treat Parkinson's disease PD and restless legs syndrome RLS. Common side effects include sleepiness, vomiting, and dizziness. It was approved for medical use in the United States in Ropinirole is prescribed for mainly Parkinson's disease , RLS and extrapyramidal symptoms.

It can also reduce the side effects caused by selective serotonin reuptake inhibitors, including Parkinsonism syndrome as well as sexual dysfunction and erectile dysfunction caused by either SSRIs [7] or antipsychotics. Ropinirole is available in various preparations, ranging from a 0.

The primary reason is dose titration. For Parkinson's disease, the maximum recommended dose is 24 mg per day, taken in three separate doses spread throughout the day. For RLS, the maximum recommended dose is 4 mg per day, taken 1 to 3 hours before bedtime.

A week open label study had a mean dosage of 1. Ropinirole can cause nausea, dizziness, hallucinations, orthostatic hypotension , and sudden sleep attacks during the daytime.

Unusual side effects specific to D 3 agonists such as ropinirole and pramipexole can include hypersexuality , punding and compulsive gambling , even in patients without a history of these behaviours. Ropinirole is also known to cause an effect known as "augmentation" when used to treat restless legs syndrome, where over time treatment with dopamine agonists will cause RLS symptoms to become more severe.

This usually leads to constant dosage increases in an attempt to offset the symptom progression. Symptoms will return to the level of severity they were experienced at before treatment was initiated if the drug is stopped; however, both ropinirole and pramipexole are known to cause painful withdrawal effects when treatment is stopped and the process of taking a patient who has been using the medication long-term off of these drugs is often very difficult and generally should be supervised by a medical professional.

Ropinirole acts as a D 2 , D 3 , and D 4 dopamine receptor agonist with highest affinity for D 3 , which are mostly found in the limbic areas. At doses greater than 24 mg, CYP2D6 may be inhibited, although this has been tested only in vitro.

Reddy's Laboratories and Sun Pharmaceutical. The discovery of the drug's utility in RLS has been used as an example of successful drug repurposing. From Wikipedia, the free encyclopedia. IUPAC name. DB Y. D Y. Interactive image. Clinical Pharmacokinetics. PMID Pharmaceutical Press. ISBN American Society of Health-System Pharmacists. Retrieved 3 March Retrieved 16 October November Sleep Med. Mayo Clinic Proceedings. PMC Archived from the original PDF on Retrieved Neuropsychiatric Disease and Treatment.

ISSN Pharmacology Biochemistry and Behavior. S2CID Drug Discovery. Mary Ann Liebert. ISSN X. Note: The opinion that ropinirole's use in RLS was a successful example of drug repurposes was reported as being that of Josef Scheiber, a post-doctoral fellow at the Novartis Institutes for BioMedical Research.

Huffington Post. Antiparkinson agents N Levodopa Melevodopa. Rasagiline Safinamide Selegiline. Entacapone Opicapone Tolcapone. Benserazide Carbidopa. Amantadine Budipine Istradefylline Methylxanthines e. Dopamine receptor modulators. Diphenidine Ephenidine Fluorolintane Methoxphenidine. Dextrallorphan Dextromethorphan Dextrorphan Racemethorphan Racemorphan. Calea zacatechichi Silene capensis Galantamine.

Glaucine Isoaminile Noscapine Pukateine. Sexual dysfunction pharmacotherapies. Androgens e. See also: Drugs for erectile dysfunction and premature ejaculation.

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Namespaces Article Talk. Views Read Edit View history. Help Learn to edit Community portal Recent changes Upload file. Download as PDF Printable version. Wikimedia Commons. Liver CYP1A2 [1]. DA precursors Levodopa Melevodopa.